| + |
TYMS | up-regulates quantity
chemical modification
|
dTMP(2-) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268235 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21876188 |
In this pathway, 5,10-methyleneTHF, a one-carbon donor, is generated from serine by SHMT and used for the conversion of dUMP to dTMP in a reaction catalyzed by TYMS. The TYMS-catalyzed reaction generates dihydrofolate, which is converted to THF in an NADPH-dependent manner by DHFR. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
dUMP(2-) | up-regulates quantity
precursor of
|
dTMP(2-) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268236 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21876188 |
In this pathway, 5,10-methyleneTHF, a one-carbon donor, is generated from serine by SHMT and used for the conversion of dUMP to dTMP in a reaction catalyzed by TYMS. The TYMS-catalyzed reaction generates dihydrofolate, which is converted to THF in an NADPH-dependent manner by DHFR. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TK2 | up-regulates quantity
chemical modification
|
dTMP(2-) |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-280584 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 25215937 |
Thymidine kinase 2 (TK2, EC 27.1.21) catalyzes the transfer of the γ-phosphate group from ATP to the 5′-hydroxyl group of thymidine (dT), deoxycytidine (dC), or deoxyuridine (dU) to form their corresponding monophosphates. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
thymidine | up-regulates quantity
precursor of
|
dTMP(2-) |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-280585 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 25215937 |
Thymidine kinase 2 (TK2, EC 27.1.21) catalyzes the transfer of the γ-phosphate group from ATP to the 5′-hydroxyl group of thymidine (dT), deoxycytidine (dC), or deoxyuridine (dU) to form their corresponding monophosphates. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |