+ |
eribulin mesylate | down-regulates activity
chemical inhibition
|
TUBA4A |
0.8 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-259344 |
|
|
Homo sapiens |
|
pmid |
sentence |
16940412 |
The complex marine natural product halichondrin B was compared with NSC 707389 (E7389), a structurally simplified, synthetic macrocyclic ketone analog, which has been selected for clinical trials in human patients. NSC 707389 was invariably more potent than halichondrin B in its interactions with tubulin. Both compounds inhibited tubulin assembly, inhibited nucleotide exchange on beta-tubulin, and were noncompetitive inhibitors of the binding of radiolabeled vinblastine and dolastatin 10 to tubulin. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
eribulin mesylate | down-regulates activity
chemical inhibition
|
Tubulin |
0.8 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-259444 |
|
|
Homo sapiens |
|
pmid |
sentence |
16940412 |
The complex marine natural product halichondrin B was compared with NSC 707389 (E7389), a structurally simplified, synthetic macrocyclic ketone analog, which has been selected for clinical trials in human patients. NSC 707389 was invariably more potent than halichondrin B in its interactions with tubulin. Both compounds inhibited tubulin assembly, inhibited nucleotide exchange on beta-tubulin, and were noncompetitive inhibitors of the binding of radiolabeled vinblastine and dolastatin 10 to tubulin. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
eribulin mesylate | down-regulates activity
chemical inhibition
|
TUBB1 |
0.8 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-259345 |
|
|
Homo sapiens |
|
pmid |
sentence |
16940412 |
The complex marine natural product halichondrin B was compared with NSC 707389 (E7389), a structurally simplified, synthetic macrocyclic ketone analog, which has been selected for clinical trials in human patients. NSC 707389 was invariably more potent than halichondrin B in its interactions with tubulin. Both compounds inhibited tubulin assembly, inhibited nucleotide exchange on beta-tubulin, and were noncompetitive inhibitors of the binding of radiolabeled vinblastine and dolastatin 10 to tubulin. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |