Relation Results

Summary

Name nisoxetine
Synonyms 3-(2-Methoxyphenoxy)-N-methyl-3-phenylpropylamine (ChemIDplus), 3-(o-Methoxyphenoxy)-N-methyl-3-phenylpropylamine (ChemIDplus), DL-N-Methyl-3-(o-methoxyphenoxy)-N-methyl-3-phenylpropylamine (ChemIDplus), N-Methyl-gamma-(2-methylphenoxy)phenylpropanolamine (ChemIDplus), nisoxetina (WHO MedNet), nisoxetine (KEGG DRUG), nisoxetine (WHO MedNet), nisoxetinum (WHO MedNet)
IUPAC 3-(2-methoxyphenoxy)-N-methyl-3-phenylpropan-1-amine
Formula C17H21NO2
PRIMARY ID
(Read more)
CHEBI:73410
Type chemical
Relations 1

Viewer

Type: Score: Layout: SPV 
0.8nisoxetineSLC6A2

Relations

Regulator
Mechanism
target
score
+ down-regulates activity img/direct_inhibition.png chemical inhibition SLC6A2 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-257797 Homo sapiens HEK-293 Cell
pmid sentence
For [3H]paroxetine, [3H]citalopram, [3H]nisoxetine, and [3H]WIN35,428 the following KD values were obtained on the human monoamine transporters hSERT, hNET, and hDAT by homologous competition experiments: 0.69 nM [3H]paroxetine, 4.46 nM [3H]citalopram, 6.77 nM [3H]nisoxetine, and 24.1 [3H]WIN35,428. 
Publications: 1 Organism: Homo Sapiens
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