+ |
nalbuphine | up-regulates activity
chemical activation
|
OPRM1 |
0.8 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-258041 |
|
|
Cricetulus longicaudatus |
CHO Cell |
pmid |
sentence |
19282177 |
A series of novel high affinity opioid receptor ligands have been made whereby the phenolic-OH group of nalbuphine, naltrexone methiodide, 6-desoxonaltrexone, hydromorphone and naltrindole was replaced by a carboxamido group and the furan ring was opened to the corresponding 4-OH derivatives. These furan ring “open” derivatives display very high affinity for μ and κ receptors and much less affinity for δ. |
|
Publications: |
1 |
Organism: |
Cricetulus Longicaudatus |
+ |
nalbuphine | up-regulates activity
chemical activation
|
OPRD1 |
0.8 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-258144 |
|
|
Cricetulus longicaudatus |
CHO Cell |
pmid |
sentence |
19282177 |
A series of novel high affinity opioid receptor ligands have been made whereby the phenolic-OH group of nalbuphine, naltrexone methiodide, 6-desoxonaltrexone, hydromorphone and naltrindole was replaced by a carboxamido group and the furan ring was opened to the corresponding 4-OH derivatives. These furan ring “open” derivatives display very high affinity for μ and κ receptors and much less affinity for δ. |
|
Publications: |
1 |
Organism: |
Cricetulus Longicaudatus |
+ |
nalbuphine | up-regulates activity
chemical activation
|
OPRK1 |
0.8 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-258658 |
|
|
Cricetulus griseus |
|
pmid |
sentence |
9262330 |
We recently cloned a human kappa opioid receptor and stably expressed it in Chinese hamster ovary (CHO) cells. In this study, the effects of activation of the human kappa receptor by agonists on [35S]GTPgammaS binding to CHO cell membranes were examined.. The rank order of potencies of opioid ligands tested in stimulating [35S]GTPgammaS binding was dynorphin A 1-17 > (+/-)-ethylketocyclazocine > beta-funaltrexamine, (-)-U50,488H, tifluadom > nalorphine > pentazocine, nalbuphine > buprenorphine. |
|
Publications: |
1 |
Organism: |
Cricetulus Griseus |