+ |
2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione | up-regulates activity
chemical activation
|
CRBN |
0.8 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-234786 |
|
|
Homo sapiens |
|
pmid |
sentence |
20223979 |
We identified cereblon (CRBN) as a thalidomide-binding protein. CRBN forms an E3 ubiquitin ligase complex with damaged DNA binding protein 1 (DDB1) and Cul4A that is important for limb outgrowth and expression of the fibroblast growth factor Fgf8 in zebrafish and chicks |
|
Publications: |
1 |
Organism: |
Homo Sapiens |