4.0
Summary
| Name |  trametinib
|
| Synonyms | GSK 1120212 (ChemIDplus), JTP 74057 (ChemIDplus), trametinib (WHO MedNet), trametinib (WHO MedNet), trametinib (WHO MedNet), trametinibum (WHO MedNet) |
| IUPAC | N-(3-{3-cyclopropyl-5-[(2-fluoro-4-iodophenyl)amino]-6,8-dimethyl-2,4,7-trioxo-3,4,6,7-tetrahydropyrido[4,3-d]pyrimidin-1(2H)-yl}phenyl)acetamide |
| Formula | C26H23FIN5O4 |
| PRIMARY ID (Read more) |
CHEBI:75998 |
| Type | chemical |
| Relations | 7 |
| Pathways | SARS-CoV MAPK PERTURBATION |
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Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | trametinib | down-regulates activity 
chemical inhibition
|
MEK1/2 | 0.8 |
| Publications: | 2 | Organism: | Homo Sapiens | |
| Pathways: | SARS-CoV MAPK PERTURBATION | |||
| + | trametinib | down-regulates activity
chemical inhibition
|
MAP2K1 | 0.8 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | trametinib | down-regulates activity
chemical inhibition
|
MAP2K2 | 0.8 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | trametinib | down-regulates
chemical inhibition
|
MEK1/2 | 0.8 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | SARS-CoV MAPK PERTURBATION | |||
| + | trametinib | down-regulates
chemical inhibition
|
MAP2K2 | 0.8 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | trametinib | down-regulates
chemical inhibition
|
MAP2K1 | 0.8 |
| Publications: | 1 | Organism: | Homo Sapiens | |