3.0
Summary
| Name |  selumetinib
|
| Synonyms | ARRY 142886 (ChemIDplus), ARRY-142886 (ChemIDplus), ARRY142886 (ChEBI), AZD 6244 (ChemIDplus), AZD-6244 (ChEBI), AZD6244 (ChemIDplus), selumetinib (WHO MedNet), selumetinib (WHO MedNet), selumetinib (WHO MedNet), selumetinibum (WHO MedNet) |
| IUPAC | 5-[(4-bromo-2-chlorophenyl)amino]-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-1H-benzimidazole-6-carboxamide |
| Formula | C17H15BrClFN4O3 |
| PRIMARY ID (Read more) |
CHEBI:90227 |
| Type | chemical |
| Relations | 5 |
| Pathways | SARS-CoV MAPK PERTURBATION |
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Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | selumetinib | down-regulates activity 
chemical inhibition
|
ERK1/2 | 0.8 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | SARS-CoV MAPK PERTURBATION | |||
| + | selumetinib | down-regulates
chemical inhibition
|
MAP2K1 | 0.8 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | selumetinib | down-regulates
chemical inhibition
|
MEK1/2 | 0.8 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | SARS-CoV MAPK PERTURBATION | |||
| + | selumetinib | down-regulates activity
chemical inhibition
|
MAP2K1 | 0.8 |
| Publications: | 1 | Organism: | In Vitro | |
| + | selumetinib | down-regulates activity
chemical inhibition
|
MAP2K2 | 0.8 |
| Publications: | 1 | Organism: | In Vitro | |