Relation Results

Summary

Name SGX-523
Synonyms SGX-523 (ChemIDplus), SGX523 (ChemIDplus)
IUPAC 6-{[6-(1-methyl-1H-pyrazol-4-yl)[1,2,4]triazolo[4,3-b]pyridazin-3-yl]sulfanyl}quinoline
Formula C18H13N7S
PRIMARY ID
(Read more)		 CHEBI:90624
Type chemical
Relations 2

Viewer

Type: Score: Layout: SPV 
0.8SGX-523MET

Search Tools

Refine search:

  • by mechanism


  • by effect
  • by organism:


  • by tissue:


  • by cell-line

Relations
Regulator
Mechanism
target
score ℹ
+ SGX-523down-regulates img/direct_inhibition.png chemical inhibition MET 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-206905 Homo sapiens
pmid sentence
Publications: 1 Organism: Homo Sapiens
+ SGX-523down-regulates activity img/direct_inhibition.png chemical inhibition MET 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-258282 in vitro
pmid sentence
Our data set represents the most detailed comprehensive assessment of the reactivity of known and clinical kinase inhibitors across the kinome published to date. | The data also show that for at least 15 of the 27 kinases that are the primary, intended targets for the compounds tested and that are represented in the assay panel, selective inhibitors, as assessed by both absolute selectivity across the kinome and selectivity relative to the primary target, are among the 72 tested here.
Publications: 1 Organism: In Vitro
a simple tooltip