Relation Results

Summary

Name anthra[1,9-cd]pyrazol-6(2H)-one
Synonyms 1,9-Pyrazoloanthrone (ChemIDplus), 2H-dibenzo[cd,g]indazol-6-one (ChEBI), C.I. 70300 (ChemIDplus), Pyrazolanthrone (ChemIDplus), Pyrazoleanthrone (ChemIDplus), SP 600125 (ChEBI)
IUPAC dibenzo[cd,g]indazol-6(2H)-one
Formula C14H8N2O
PRIMARY ID
(Read more)
CHEBI:90695
Type chemical
Relations 8

Viewer

Type: Score: Layout: SPV 
0.80.80.80.80.80.80.8anthra[1,9-cd]pyrazol-6(2H)-oneMAPK9MAPK10JNKNTRK1FLT3MAPK8AURKA

Relations

Regulator
Mechanism
target
score
+ down-regulates img/direct_inhibition.png chemical inhibition MAPK9 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-111986 Homo sapiens
pmid sentence
We report the identification of an anthrapyrazolone series with significant jnk1, -2, and -3 (k(i) = 0.19 microm).
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition MAPK10 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-111980 Homo sapiens
pmid sentence
We report the identification of an anthrapyrazolone series with significant jnk1, -2, and -3 (k(i) = 0.19 microm). To determine whether jnk activity is required for stress-induced translocation of bax to the mitochondria, we examined the effect of sp600125, a jnk inhibitor.
Identifier Residue Sequence Organism Cell Line
SIGNOR-124034 Homo sapiens
pmid sentence
We report the identification of an anthrapyrazolone series with significant jnk1, -2, and -3 (k(i) = 0.19 microm). To determine whether jnk activity is required for stress-induced translocation of bax to the mitochondria, we examined the effect of sp600125, a jnk inhibitor.
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition JNK 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-269885 Homo sapiens
pmid sentence
We report the identification of an anthrapyrazolone series with significant jnk1, -2, and -3 (k(i) = 0.19 microm). To determine whether jnk activity is required for stress-induced translocation of bax to the mitochondria, we examined the effect of sp600125, a jnk inhibitor.
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition NTRK1 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-170617 Homo sapiens
pmid sentence
In comparison, in the same assay conditions, the previously reported mps1 inhibitor sp600125 (13) was 10-fold less potent than nms-p715 on mps1 and, in addition, it was highly unspecific, being more active on at least 12 kinases including mitotic kinases.
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition FLT3 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-170614 Homo sapiens
pmid sentence
In comparison, in the same assay conditions, the previously reported mps1 inhibitor sp600125 (13) was 10-fold less potent than nms-p715 on mps1 and, in addition, it was highly unspecific, being more active on at least 12 kinases including mitotic kinases with ic50 values well below 1 ?mol/l
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition MAPK8 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-111983 Homo sapiens
pmid sentence
We report the identification of an anthrapyrazolone series with significant jnk1, -2, and -3 (k(i) = 0.19 microm).
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition AURKA 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-170611 Homo sapiens
pmid sentence
In comparison, in the same assay conditions, the previously reported mps1 inhibitor sp600125 (13) was 10-fold less potent than nms-p715 on mps1 and, in addition, it was highly unspecific, being more active on at least 12 kinases including mitotic kinases.
Publications: 1 Organism: Homo Sapiens
a simple tooltip