| + |
1-methyl-3,6-dihydro-2H-pyridine-5-carboxylic acid prop-2-ynyl ester | up-regulates activity 
chemical activation
|
CHRM4 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-258634 |
|
|
Cricetulus griseus |
CHO Cell |
| pmid |
sentence |
| 9224827 |
We investigated whether the allosteric modulators can also increase the affinity of receptors for their agonists. Twelve agonists and five allosteric modulators were tested in experiments on membranes of CHO cells that had been stably transfected with genes for the M1-M4 receptor subtypes. Affinities of agonists for the M1–M4 receptor subtypes were determined according to the ability of the agonist to inhibit [3H]NMS binding in the presence of 0.5 mM GTP; in this way, the low affinity binding of agonists was measured.The computed pKi and nH values are summarized in Table 2. |
|
| Publications: |
1 |
Organism: |
Cricetulus Griseus |
| + |
1-methyl-3,6-dihydro-2H-pyridine-5-carboxylic acid prop-2-ynyl ester | up-regulates activity
chemical activation
|
CHRM1 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-258636 |
|
|
Cricetulus griseus |
CHO Cell |
| pmid |
sentence |
| 9224827 |
We investigated whether the allosteric modulators can also increase the affinity of receptors for their agonists. Twelve agonists and five allosteric modulators were tested in experiments on membranes of CHO cells that had been stably transfected with genes for the M1-M4 receptor subtypes. Affinities of agonists for the M1–M4 receptor subtypes were determined according to the ability of the agonist to inhibit [3H]NMS binding in the presence of 0.5 mM GTP; in this way, the low affinity binding of agonists was measured.The computed pKi and nH values are summarized in Table 2. |
|
| Publications: |
1 |
Organism: |
Cricetulus Griseus |
| + |
1-methyl-3,6-dihydro-2H-pyridine-5-carboxylic acid prop-2-ynyl ester | up-regulates activity
chemical activation
|
CHRM3 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-258637 |
|
|
Cricetulus griseus |
CHO Cell |
| pmid |
sentence |
| 9224827 |
We investigated whether the allosteric modulators can also increase the affinity of receptors for their agonists. Twelve agonists and five allosteric modulators were tested in experiments on membranes of CHO cells that had been stably transfected with genes for the M1-M4 receptor subtypes. Affinities of agonists for the M1–M4 receptor subtypes were determined according to the ability of the agonist to inhibit [3H]NMS binding in the presence of 0.5 mM GTP; in this way, the low affinity binding of agonists was measured.The computed pKi and nH values are summarized in Table 2. |
|
| Publications: |
1 |
Organism: |
Cricetulus Griseus |
| + |
1-methyl-3,6-dihydro-2H-pyridine-5-carboxylic acid prop-2-ynyl ester | up-regulates activity
chemical activation
|
CHRM2 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-258635 |
|
|
Cricetulus griseus |
CHO Cell |
| pmid |
sentence |
| 9224827 |
We investigated whether the allosteric modulators can also increase the affinity of receptors for their agonists. Twelve agonists and five allosteric modulators were tested in experiments on membranes of CHO cells that had been stably transfected with genes for the M1-M4 receptor subtypes. Affinities of agonists for the M1–M4 receptor subtypes were determined according to the ability of the agonist to inhibit [3H]NMS binding in the presence of 0.5 mM GTP; in this way, the low affinity binding of agonists was measured.The computed pKi and nH values are summarized in Table 2. |
|
| Publications: |
1 |
Organism: |
Cricetulus Griseus |
3.0
1-methyl-3,6-dihydro-2H-pyridine-5-carboxylic acid prop-2-ynyl ester
