+ |
Terfenadine | down-regulates activity
chemical inhibition
|
HRH1 |
0.8 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-257825 |
|
|
in vitro |
|
pmid |
sentence |
19660947 |
hERG activity was initially determined in a high throughput patch clamp screening assay (Ionworks)5 while a human H1 binding assay was used to determine H1 binding affinity.6 Selected results were confirmed in vitro using an IonWorks Quattro patch clamp assay and in vivo in the guinea pig.7, 8 Histamine H1activity was confirmed in vivo in the guinea pig.7 |
|
Publications: |
1 |
Organism: |
In Vitro |
+ |
Terfenadine | down-regulates activity
chemical inhibition
|
KCNH2 |
0.8 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-258673 |
|
|
Homo sapiens |
HEK-293 Cell |
pmid |
sentence |
9395068 |
We have previously shown that terfenadine can inhibit both Kv1.5 and HERG with its effects on HERG being approximately 10‐fold more potent |
|
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-257826 |
|
|
in vitro |
|
pmid |
sentence |
19660947 |
hERG activity was initially determined in a high throughput patch clamp screening assay (Ionworks)5 while a human H1 binding assay was used to determine H1 binding affinity.6 Selected results were confirmed in vitro using an IonWorks Quattro patch clamp assay and in vivo in the guinea pig.7, 8 Histamine H1activity was confirmed in vivo in the guinea pig.7 |
|
Publications: |
2 |
Organism: |
Homo Sapiens, In Vitro |