Relation Results

Summary

Name 2-[(4S)-6-(4-chlorophenyl)-8-methoxy-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-yl]-N-ethylacetamide
Synonyms
IUPAC
Formula C22H22ClN5O2
PRIMARY ID
(Read more)		 CHEBI:95082
Type chemical
Relations 3

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Type: Score: Layout: SPV 
0.80.80.82-[(4S)-6-(4-chlorophenyl)-8-methoxy-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-yl]-N-ethylacetamideBRD2BRD4BRD3

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Relations
Regulator
Mechanism
target
score ℹ
+ 2-[(4S)-6-(4-chlorophenyl)-8-methoxy-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-yl]-N-ethylacetamidedown-regulates activity img/direct_inhibition.png chemical inhibition BRD2 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-262202 in vitro
pmid sentence
This paper describes the discovery and structure-activity relationships (SAR) of potent benzodiazepine inhibitors that disrupt the function of the BET family of bromodomains (BRD2, BRD3, and BRD4). This work has yielded a potent, selective compound I-BET762 that is now under evaluation
Publications: 1 Organism: In Vitro
+ 2-[(4S)-6-(4-chlorophenyl)-8-methoxy-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-yl]-N-ethylacetamidedown-regulates activity img/direct_inhibition.png chemical inhibition BRD4 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-262204 in vitro
pmid sentence
This paper describes the discovery and structure-activity relationships (SAR) of potent benzodiazepine inhibitors that disrupt the function of the BET family of bromodomains (BRD2, BRD3, and BRD4). This work has yielded a potent, selective compound I-BET762 that is now under evaluation
Publications: 1 Organism: In Vitro
+ 2-[(4S)-6-(4-chlorophenyl)-8-methoxy-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-yl]-N-ethylacetamidedown-regulates activity img/direct_inhibition.png chemical inhibition BRD3 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-262203 in vitro
pmid sentence
This paper describes the discovery and structure-activity relationships (SAR) of potent benzodiazepine inhibitors that disrupt the function of the BET family of bromodomains (BRD2, BRD3, and BRD4). This work has yielded a potent, selective compound I-BET762 that is now under evaluation
Publications: 1 Organism: In Vitro
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