| + |
ATP7B | up-regulates quantity 
relocalization
|
copper(1+) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-272297 |
|
|
|
|
| pmid |
sentence |
| 24706876 |
WD is caused by mutations in ATP7B, a transporter that loads Cu(I) onto newly synthesized cupro-enzymes in the trans-Golgi network (TGN) and exports excess copper out of cells by trafficking from the TGN to the plasma membrane. |
|
| Publications: |
1 |
| + |
copper(1+) | up-regulates activity
chemical activation
|
SOD1 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-272299 |
|
|
|
|
| pmid |
sentence |
| 1542024 |
Copper as a cofactor and regulator of copper,zinc superoxide dismutase |
|
| Publications: |
1 |
| + |
copper(1+) | up-regulates activity
chemical activation
|
SOD3 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-272301 |
|
|
|
|
| pmid |
sentence |
| 1542024 |
Copper as a cofactor and regulator of copper,zinc superoxide dismutase |
|
| Publications: |
1 |
| + |
ATP7A | up-regulates quantity
relocalization
|
copper(1+) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-272298 |
|
|
|
|
| pmid |
sentence |
| 28389643 |
Menkes disease (MD) is caused by mutations in ATP7A, encoding a copper- transporting P-type ATPase which exhibits copper-dependent trafficking. ATP7A is found in the Trans-Golgi Network (TGN) at low copper concentrations, and in the post-Golgi compartments and the plasma membrane at higher concentrations. |
|
| Publications: |
1 |
| + |
copper(1+) | up-regulates activity
chemical activation
|
SOD2 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-272300 |
|
|
|
|
| pmid |
sentence |
| 1542024 |
Copper as a cofactor and regulator of copper,zinc superoxide dismutase |
|
| Publications: |
1 |
3.0
copper(1+)