Summary

Name FOXE1
Full Name Forkhead box protein E1
Synonyms Forkhead box protein E2, Forkhead-related protein FKHL15, HFKH4, HNF-3/fork head-like protein 5, HFKL5, Thyroid transcription factor 2, TTF-2 | FKHL15, FOXE2, TITF2, TTF2
Primary ID O00358
Links - -
Type protein
Relations 3
Function Transcription factor that binds consensus sites on a variety of gene promoters and activate their transcription. Involved in proper palate formation, most probably through the expression of MSX1 and TGFB3 genes which are direct targets of this transcription factor. Also implicated in thyroid gland morphogenesis. May indirectly play a role in cell growth and migration through the regulation of WNT5A expression.

Viewer

Relations

Regulator Mechanism target score
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation TPO 0.396
Publications: 1 Organism: Homo Sapiens
Tissue: Hypophysis
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation TGFB3 0.36
Publications: 1 Organism: Mus Musculus
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation MSX1 0.399
Publications: 1 Organism: Mus Musculus