Relation Results

Name	PSMD14
Full Name	26S proteasome non-ATPase regulatory subunit 14
Synonyms	26S proteasome regulatory subunit RPN11, 26S proteasome-associated PAD1 homolog 1 \| POH1
Primary ID	O00487
Links	- -
Type	protein
Relations	1
Function	Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. The PSMD14 subunit is a metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains within the complex. Plays a role in response to double-strand breaks (DSBs)