3.0
Summary
| Name |  BIN1
|
| Full Name | Myc box-dependent-interacting protein 1 |
| Synonyms | Amphiphysin II, Amphiphysin-like protein, Box-dependent myc-interacting protein 1, Bridging integrator 1 | AMPHL |
| Primary ID | O00499 |
| Links |  -  -  |
| Type | protein |
| Relations | 2 |
| Function | Is a key player in the control of plasma membrane curvature, membrane shaping and membrane remodeling. Required in muscle cells for the formation of T-tubules, tubular invaginations of the plasma membrane that function in depolarization-contraction coupling (PubMed:24755653). Is a negative regulator of endocytosis (By similarity). Is also involved in the regulation of intracellular vesicles sorting, modulation of BACE1 trafficking and the control of amyloid-beta production (PubMed:27179792). In neuronal circuits, endocytosis regulation may influence the internalization of PHF-tau aggregates (By similarity). May be involved in the regulation of MYC activity and the control cell proliferation (PubMed:8782822). Has actin bundling activity and stabilizes actin filaments against depolymerization in vitro (PubMed:28893863). |
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Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | MYOD1/SWI/SNF complex | up-regulates quantity by expression 
transcriptional regulation
|
BIN1 | 0.282 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | GDNF | up-regulates quantity by expression
transcriptional regulation
|
BIN1 | 0.2 |
| Publications: | 1 | Organism: | Rattus Norvegicus | |