Relation Results

Summary

Name DDX3X
Full Name ATP-dependent RNA helicase DDX3X
Synonyms DEAD box protein 3, X-chromosomal, DEAD box, X isoform, Helicase-like protein 2, HLP2 | DBX, DDX3
Primary ID O00571
Links - -
Type protein
Relations 11
Function Multifunctional ATP-dependent RNA helicase (PubMed:17357160, PubMed:21589879, PubMed:31575075). The ATPase activity can be stimulated by various ribo- ...
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Type: Score: Layout: SPV 
0.3450.3010.2580.6470.5860.36CyclinB/CDK1DDX3XCDK1FUSEIF4EPABPC1SP1

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▶Modifications Tables

Relations
Regulator
Mechanism
target
score ℹ
+ CyclinB/CDK1down-regulates img/direct_inhibition.png phosphorylation DDX3X 0.345
Identifier Residue Sequence Organism Cell Line
SIGNOR-216868 Thr204 LTRYTRPtPVQKHAI Homo sapiens
pmid sentence
Thr204 to glu204 ddx3 mutant protein lost its function, suggesting that phosphorylation at thr204 affects ddx3 function. Thr204 was phosphorylated by cyclin b/cdc2. Thr323 in motif ib was also phosphorylated by cyclin b/cdc2 kinase. We propose a novel function of cyclin b/cdc2 kinase in mitosis, which is to cause a loss of ddx3 function to repress cyclin a expression and to decrease ribosome biogenesis and translation during mitosis.
Identifier Residue Sequence Organism Cell Line
SIGNOR-216872 Thr323 GCHLLVAtPGRLVDM Homo sapiens
pmid sentence
Thr204 to glu204 ddx3 mutant protein lost its function, suggesting that phosphorylation at thr204 affects ddx3 function. Thr204 was phosphorylated by cyclin b/cdc2. Thr323 in motif ib was also phosphorylated by cyclin b/cdc2 kinase. We propose a novel function of cyclin b/cdc2 kinase in mitosis, which is to cause a loss of ddx3 function to repress cyclin a expression and to decrease ribosome biogenesis and translation during mitosis.
Publications: 2 Organism: Homo Sapiens
+ CDK1down-regulates img/direct_inhibition.png phosphorylation DDX3X 0.301
Identifier Residue Sequence Organism Cell Line
SIGNOR-141565 Thr204 LTRYTRPtPVQKHAI Homo sapiens
pmid sentence
Thr204 to glu204 ddx3 mutant protein lost its function, suggesting that phosphorylation at thr204 affects ddx3 function. Thr204 was phosphorylated by cyclin b/cdc2. Thr323 in motif ib was also phosphorylated by cyclin b/cdc2 kinase. We propose a novel function of cyclin b/cdc2 kinase in mitosis, which is to cause a loss of ddx3 function to repress cyclin a expression and to decrease ribosome biogenesis and translation during mitosis.
Identifier Residue Sequence Organism Cell Line
SIGNOR-141569 Thr323 GCHLLVAtPGRLVDM Homo sapiens
pmid sentence
Thr204 to glu204 ddx3 mutant protein lost its function, suggesting that phosphorylation at thr204 affects ddx3 function. Thr204 was phosphorylated by cyclin b/cdc2. Thr323 in motif ib was also phosphorylated by cyclin b/cdc2 kinase. We propose a novel function of cyclin b/cdc2 kinase in mitosis, which is to cause a loss of ddx3 function to repress cyclin a expression and to decrease ribosome biogenesis and translation during mitosis.
Publications: 2 Organism: Homo Sapiens
+ FUSdown-regulates activity img/direct_inhibition.png relocalization DDX3X 0.258
Identifier Residue Sequence Organism Cell Line
SIGNOR-262811 Homo sapiens
pmid sentence
We found that ALS mutants of FUS co-localized with Caprin-1, DDX3X, and DHX9 in cytoplasmic inclusions that could lead to the mis-regulation of their respective pathways, providing further clues to the mechanism of ALS pathogenesis.|FUS interacting proteins were sequestered into the cytoplasmic mutant FUS inclusions that could lead to their mis-regulation or loss of function, contributing to ALS pathogenesis. | We also demonstrated the co-localization of DHX9, DDX3X and Caprin-1 with cytoplasmic EGFP-P525L mutant FUS inclusions in primary cortical neurons
Publications: 1 Organism: Homo Sapiens
+ DDX3Xdown-regulates activity img/direct_inhibition.png binding EIF4E 0.647
Identifier Residue Sequence Organism Cell Line
SIGNOR-269200 Homo sapiens HuH-7 Cell
pmid sentence
DDX3 is a human RNA helicase with plethoric functions. we identified translation initiation factor eukaryotic initiation factor 4E (eIF4E) as a DDX3-binding partner. Interestingly, DDX3 utilizes a consensus eIF4E-binding sequence YIPPHLR to interact with the functionally important dorsal surface of eIF4E in a similar manner to other eIF4E-binding proteins. Furthermore, cap affinity chromatography analysis suggests that DDX3 traps eIF4E in a translationally inactive complex by blocking interaction with eIF4G.
Identifier Residue Sequence Organism Cell Line
SIGNOR-269193 Homo sapiens HuH-7 Cell
pmid sentence
DDX3 is a human RNA helicase with plethoric functions. we identified translation initiation factor eukaryotic initiation factor 4E (eIF4E) as a DDX3-binding partner. Interestingly, DDX3 utilizes a consensus eIF4E-binding sequence YIPPHLR to interact with the functionally important dorsal surface of eIF4E in a similar manner to other eIF4E-binding proteins. Furthermore, cap affinity chromatography analysis suggests that DDX3 traps eIF4E in a translationally inactive complex by blocking interaction with eIF4G.
Publications: 2 Organism: Homo Sapiens
+ DDX3Xup-regulates activity img/direct-activation.png binding PABPC1 0.586
Identifier Residue Sequence Organism Cell Line
SIGNOR-269194 Homo sapiens
pmid sentence
In the present study, we indentified the SG marker PABP1 [poly(A)-binding protein 1] as another direct interaction partner of DDX3. Interestingly, down-regulation of DDX3 interfered with SG assembly, led to nuclear accumulation of PABP1 and reduced cell viability following stress. Conversely, supplementation with a shRNA (short hairpin RNA)-resistant DDX3 restored SG formation, the translocation of PABP1 into SGs and cell survival.
Identifier Residue Sequence Organism Cell Line
SIGNOR-269201 Homo sapiens
pmid sentence
In the present study, we indentified the SG marker PABP1 [poly(A)-binding protein 1] as another direct interaction partner of DDX3. Interestingly, down-regulation of DDX3 interfered with SG assembly, led to nuclear accumulation of PABP1 and reduced cell viability following stress. Conversely, supplementation with a shRNA (short hairpin RNA)-resistant DDX3 restored SG formation, the translocation of PABP1 into SGs and cell survival.
Publications: 2 Organism: Homo Sapiens
+ DDX3Xup-regulates activity img/direct-activation.png binding SP1 0.36
Identifier Residue Sequence Organism Cell Line
SIGNOR-269202 Homo sapiens
pmid sentence
DDX3X enhances transcription by interacting with transcription factors to promote their binding to the promoter of the target gene. The best characterized mechanism is its cooperation with the transcription factor SP1. The downstream genes of DDX3X-SP1-mediated transactivation include P21, KRAS, and MDM2
Identifier Residue Sequence Organism Cell Line
SIGNOR-269195 Homo sapiens
pmid sentence
DDX3X enhances transcription by interacting with transcription factors to promote their binding to the promoter of the target gene. The best characterized mechanism is its cooperation with the transcription factor SP1. The downstream genes of DDX3X-SP1-mediated transactivation include P21, KRAS, and MDM2
Publications: 2 Organism: Homo Sapiens
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