Summary

Name CCL21
Full Name C-C motif chemokine 21
Synonyms 6Ckine, Beta-chemokine exodus-2, Secondary lymphoid-tissue chemokine, SLC, Small-inducible cytokine A21 | SCYA21
Primary ID O00585
Links - -
Type protein
Relations 2
Function Inhibits hemopoiesis and stimulates chemotaxis. Chemotactic in vitro for thymocytes and activated T-cells, but not for B-cells, macrophages, or neutrophils. Shows preferential activity towards naive T-cells. May play a role in mediating homing of lymphocytes to secondary lymphoid organs. Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4.

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Relations

Regulator Mechanism target score
+ up-regulates img/direct-activation.png binding CCR7 0.78
Publications: 1 Organism: Homo Sapiens
Tissue: Kidney
+ up-regulates activity img/direct-activation.png binding ACKR4 0.65
Publications: 1 Organism: Homo Sapiens