Full Name Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2
Synonyms Nuclear LIM interactor-interacting factor 2, NLI-interacting factor 2, Protein OS-4, Small C-terminal domain phosphatase 2, Small CTD phosphatase 2, SCP2 | NIF2, OS4, SCP2
Primary ID O14595
Links - -
Type protein
Relations 12
Function Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residue repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells. May contribute to the development of sarcomas.


Modifications Tables


Regulator Mechanism target score
+ down-regulates activity img/direct_inhibition.png dephosphorylation SMAD1
Publications: 4 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png dephosphorylation SMAD3
Publications: 3 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png dephosphorylation SMAD2
Publications: 4 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png dephosphorylation SMAD1 0.44
Publications: 1 Organism: Homo Sapiens