3.0
Summary
| Name |  RIOK3View Modifications |
| Full Name | Serine/threonine-protein kinase RIO3 |
| Synonyms | RIO kinase 3, sudD homolog | SUDD |
| Primary ID | O14730 |
| Links |  -  -  |
| Type | protein |
| Relations | 1 |
| Function | Involved in regulation of type I interferon (IFN)-dependent immune response which plays a critical role in the innate immune response against DNA and RNA viruses. May act as an adapter protein essential for the recruitment of TBK1 to IRF3 (PubMed:24807708). Phosphorylates IFIH1 on 'Ser-828' interfering with IFIH1 filament assembly on long dsRNA and resulting in attenuated IFIH1-signaling (PubMed:25865883). Can inhibit CASP10 isoform 7-mediated activation of the NF-kappaB signaling pathway (PubMed:19557502). May play a role in the biogenesis of the 40S ribosomal subunit. Involved in the processing of 21S pre-rRNA to the mature 18S rRNA (PubMed:22418843). |
phosphorylation