3.0
Summary
| Name |  AIM2
|
| Full Name | Interferon-inducible protein AIM2 |
| Synonyms | Absent in melanoma 2 | |
| Primary ID | O14862 |
| Links |  -  -  |
| Type | protein |
| Relations | 3 |
| Function | Involved in innate immune response by recognizing cytosolic double-stranded DNA and inducing caspase-1-activating inflammasome formation in macrophages. Upon binding to DNA is thought to undergo oligomerization and to associate with PYCARD initiating the recruitment of caspase-1 precusrsor and processing of interleukin-1 beta and interleukin-18. Detects cytosolic dsDNA of viral and bacterial origin in a non-sequence-specific manner. Can also trigger PYCARD-dependent, caspase-1-independent cell death that involves caspase-8 (By similarity). Tumor suppressor which may act by repressing NF-kappa-B transcriptional activity. |
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