| + |
PAMPs | up-regulates activity 
binding
|
MBL2 |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263405 |
|
|
|
|
| pmid |
sentence |
| 17204478 |
In the lectin pathway, mannose-binding lectin (MBL) and ficolins bind to pathogens and activate MBL-associated serine protease-2 (MASP-2) |
|
| Publications: |
1 |
| Pathways: | Complement Signaling |
| + |
PAMPs | up-regulates quantity 
|
MPO-ANCA |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270586 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15972951 |
In the early phase, LPS enhanced anti-MPO IgG-induced glomerular neutrophil accumulation. |using bacterial lipopolysaccharide (LPS) as the proinflammatory stimulus. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Blood Serum |
| + |
PAMPs | up-regulates
|
AP-2/clathrin vescicle |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267857 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 25720354 |
APCs have several cell surface receptors that facilitate antigen entry into antigen-processing compartments through clathrin-mediated endocytosis. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | COVID-19 Causal Network |
| + |
PAMPs | up-regulates activity
|
TLR4 |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249516 |
|
|
Homo sapiens |
Macrophage |
| pmid |
sentence |
| 19946286 |
The lipopolysaccharide (LPS) of Gram negative bacteria is a wellknown inducer of the innate immune response1. Toll-like receptor (TLR) 4 and myeloid differentiation factor 2 (MD-2) form a heterodimer that recognizes a common pattern in structurally diverse LPS molecules. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Macrophage polarization |
| + |
PAMPs | up-regulates activity
binding
|
FCN3 |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263406 |
|
|
in vitro |
|
| pmid |
sentence |
| 11907111 |
H-ficolin binds to PSA, a polysaccharide produced by Aerococcus viridans. C4 was activated by H-ficolin preparations bound to PSA which had been coated on ELISA plates. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
PAMPs | up-regulates activity
|
NLRP1 |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256425 |
|
|
|
|
| pmid |
sentence |
| 16037825 |
Among these sensors, members of the evolutionary conserved NLRs, together with AIM2 and pyrin, can assemble into a multimeric protein complex that is called the inflammasome (see poster).| An inflammasome assembles in response to a diverse range of pathogen-associated or danger-associated molecular patterns (PAMPs or DAMPs). The inflammasome platform leads to activation of caspase-1 through proximity-induced self-cleavage |
|
| Publications: |
1 |
| + |
PAMPs | up-regulates
|
TLRs |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-216295 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20404851 |
the discovery of Toll-like receptors (TLRs) in the mid-1990s showed that pathogen recognition by the innate immune system is instead actually specific, relying on germline-encoded pattern-recognition receptors (PRRs) that have evolved to detect components of foreign pathogens referred to as pathogen-associated molecular patterns (PAMPs) |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | COVID-19 Causal Network, Innate Immune Response, Inflammosome Activation, SARS-CoV INFLAMMATORY RESPONSE, Toll like receptors |
| + |
PAMPs | up-regulates activity
|
NAIP |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256424 |
|
|
|
|
| pmid |
sentence |
| 16037825 |
Among these sensors, members of the evolutionary conserved NLRs, together with AIM2 and pyrin, can assemble into a multimeric protein complex that is called the inflammasome (see poster).| An inflammasome assembles in response to a diverse range of pathogen-associated or danger-associated molecular patterns (PAMPs or DAMPs). The inflammasome platform leads to activation of caspase-1 through proximity-induced self-cleavage |
|
| Publications: |
1 |
| + |
PAMPs | up-regulates quantity
|
Pr3-ANCA |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270587 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15972951 |
In the early phase, LPS enhanced anti-MPO IgG-induced glomerular neutrophil accumulation. |using bacterial lipopolysaccharide (LPS) as the proinflammatory stimulus. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Blood Serum |
| + |
PAMPs | up-regulates activity
|
NLRP1 inflammasome |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263125 |
|
|
|
|
| pmid |
sentence |
| 16037825 |
Among these sensors, members of the evolutionary conserved NLRs, together with AIM2 and pyrin, can assemble into a multimeric protein complex that is called the inflammasome (see poster).| An inflammasome assembles in response to a diverse range of pathogen-associated or danger-associated molecular patterns (PAMPs or DAMPs). The inflammasome platform leads to activation of caspase-1 through proximity-induced self-cleavage |
|
| Publications: |
1 |
| Pathways: | Inflammosome Activation |
| + |
PAMPs | up-regulates activity
|
NLRP3 inflammasome |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263127 |
|
|
|
|
| pmid |
sentence |
| 16037825 |
Among these sensors, members of the evolutionary conserved NLRs, together with AIM2 and pyrin, can assemble into a multimeric protein complex that is called the inflammasome (see poster).| An inflammasome assembles in response to a diverse range of pathogen-associated or danger-associated molecular patterns (PAMPs or DAMPs). The inflammasome platform leads to activation of caspase-1 through proximity-induced self-cleavage |
|
| Publications: |
1 |
| Pathways: | COVID-19 Causal Network, Inflammosome Activation, SARS-CoV INFLAMMATORY RESPONSE |
| + |
PAMPs | up-regulates activity
|
MEFV |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256426 |
|
|
|
|
| pmid |
sentence |
| 16037825 |
Among these sensors, members of the evolutionary conserved NLRs, together with AIM2 and pyrin, can assemble into a multimeric protein complex that is called the inflammasome (see poster).| An inflammasome assembles in response to a diverse range of pathogen-associated or danger-associated molecular patterns (PAMPs or DAMPs). The inflammasome platform leads to activation of caspase-1 through proximity-induced self-cleavage |
|
| Publications: |
1 |
| + |
PAMPs | up-regulates activity
binding
|
COLEC11 |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263408 |
|
|
in vitro |
|
| pmid |
sentence |
| 20956340 |
We finally show that CL-11 binds to intact bacteria, fungi, and viruses and that CL-11 decreases influenza A virus infectivity and forms complexes with DNA|it is conceivable that CL-11 plays a role in activation of the complement system and in the defense against invading microorganisms. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
PAMPs | up-regulates
|
AP-1/clathrin vescicle |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267855 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 25720354 |
APCs have several cell surface receptors that facilitate antigen entry into antigen-processing compartments through clathrin-mediated endocytosis. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PAMPs | up-regulates activity
binding
|
FCN2 |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263407 |
|
|
in vitro |
|
| pmid |
sentence |
| 11907111 |
H-ficolin binds to PSA, a polysaccharide produced by Aerococcus viridans. C4 was activated by H-ficolin preparations bound to PSA which had been coated on ELISA plates. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
PAMPs | up-regulates
|
SLC11A1 |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254039 |
|
|
Homo sapiens |
Macrophage |
| pmid |
sentence |
| 11909746 |
Functional studies in Nramp1 transfected macrophages have demonstrated that the Nramp1 protein plays a vital role in early macrophage activation [10,29,30]. Nramp1 is constitutively expressed in macrophage cell lines of the myeloid lineage (isolated peritoneal, splenic, and liver resident macrophages), and can be induced by treatment of macrophages with IFN-γ, or IFN-γ plus lipopolysaccharide (LPS) |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PAMPs | up-regulates activity
|
AIM2 |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256423 |
|
|
|
|
| pmid |
sentence |
| 16037825 |
Among these sensors, members of the evolutionary conserved NLRs, together with AIM2 and pyrin, can assemble into a multimeric protein complex that is called the inflammasome (see poster).| An inflammasome assembles in response to a diverse range of pathogen-associated or danger-associated molecular patterns (PAMPs or DAMPs). The inflammasome platform leads to activation of caspase-1 through proximity-induced self-cleavage |
|
| Publications: |
1 |
| + |
PAMPs | up-regulates activity
binding
|
ITLN1 |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-272498 |
|
|
|
|
| pmid |
sentence |
| 26148048 |
Human intelectin-1 (hIntL-1) does not bind known human glycan epitopes but does interact with multiple glycan epitopes found exclusively on microbes: β-linked D-galactofuranose (β-Galf), D-phosphoglycerol-modified glycans, heptoses, D-glycero-D-talo-oct-2-ulosonic acid (KO) and 3-deoxy-D-manno-oct-2-ulosonic acid (KDO). | This ligand selectivity suggests that hIntL-1 functions in microbial surveillance. |
|
| Publications: |
1 |
| + |
PAMPs | up-regulates
|
AP-3/clathrin vescicle |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267859 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 25720354 |
APCs have several cell surface receptors that facilitate antigen entry into antigen-processing compartments through clathrin-mediated endocytosis. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PAMPs | up-regulates activity
|
AIM2 inflammasome |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263126 |
|
|
|
|
| pmid |
sentence |
| 16037825 |
Among these sensors, members of the evolutionary conserved NLRs, together with AIM2 and pyrin, can assemble into a multimeric protein complex that is called the inflammasome (see poster).| An inflammasome assembles in response to a diverse range of pathogen-associated or danger-associated molecular patterns (PAMPs or DAMPs). The inflammasome platform leads to activation of caspase-1 through proximity-induced self-cleavage |
|
| Publications: |
1 |
| Pathways: | Inflammosome Activation |
| + |
PAMPs | up-regulates activity
|
NLRC4 inflammasome |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263124 |
|
|
|
|
| pmid |
sentence |
| 16037825 |
Among these sensors, members of the evolutionary conserved NLRs, together with AIM2 and pyrin, can assemble into a multimeric protein complex that is called the inflammasome (see poster).| An inflammasome assembles in response to a diverse range of pathogen-associated or danger-associated molecular patterns (PAMPs or DAMPs). The inflammasome platform leads to activation of caspase-1 through proximity-induced self-cleavage |
|
| Publications: |
1 |
| Pathways: | Inflammosome Activation |
3.0
PAMPs