Summary

Name CASQ2
Full Name Calsequestrin-2
Synonyms Calsequestrin, cardiac muscle isoform
Primary ID O14958
Links - -
Type protein
Relations 2
Function Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle. Calcium ions are bound by clusters of acidic residues at the protein surface, especially at the interface between subunits. Can bind around 60 Ca(2+) ions. Regulates the release of lumenal Ca(2+) via the calcium release channel RYR2; this plays an important role in triggering muscle contraction. Plays a role in excitation-contraction coupling in the heart and in regulating the rate of heart beats.

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Modifications Tables

Relations

Regulator Mechanism target score
+ img/unknown.png phosphorylation CASQ2 0.383
Publications: 1 Organism: In Vitro
+ img/unknown.png phosphorylation CASQ2 0.342
Publications: 1 Organism: In Vitro