3.0
Summary
| Name |  MCF2L
|
| Full Name | Guanine nucleotide exchange factor DBS |
| Synonyms | DBL's big sister, MCF2-transforming sequence-like protein | KIAA0362, OST |
| Primary ID | O15068 |
| Links |  -  -  |
| Type | protein |
| Relations | 2 |
| Function | Guanine nucleotide exchange factor that catalyzes guanine nucleotide exchange on RHOA and CDC42, and thereby contributes to the regulation of RHOA and CDC42 signaling pathways (By similarity). Seems to lack activity with RAC1. Becomes activated and highly tumorigenic by truncation of the N-terminus (By similarity). Isoform 5 activates CDC42 (PubMed:15157669). |
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guanine nucleotide exchange factor