Summary

Name ARPC2
Full Name Actin-related protein 2/3 complex subunit 2
Synonyms Arp2/3 complex 34 kDa subunit, p34-ARC | ARC34, ARC34
Primary ID O15144
Links - -
Type protein
Relations 1
Function Actin-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (PubMed:9230079). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (PubMed:9230079). Seems to contact the mother actin filament (PubMed:9230079). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (PubMed:29925947). The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (PubMed:29925947).

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Relations

Regulator Mechanism target score ℹ
+ ARPC2form complex img/form-complex.png binding ARP2/3 0.957
Publications: 1 Organism: Homo Sapiens