Relation Results

Summary

Name ARP2/3
Primary ID SIGNOR-C146
Links CPX-2586
Type complex
Formed by ACTR2, ARPC1A, ARPC2, ARPC3, ARPC4, ARPC5, ACTR3
Relations 19
Pathways Macropinocytosis , T cell activation

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Type: Score: Layout: SPV 
0.70.9640.960.9650.3110.9290.7880.3510.960.2840.20.810.5440.20.9190.8760.6450.542ARP2/3F-actin_assemblyARPC3ARPC2ARPC4JMYACTR2WASLWHAMMARPC5DNM1LWASH complexWASWAVE complexNHSACTR3ARPC1ACTTNWRC complex

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Relations
Regulator
Mechanism
target
score ℹ
+ ARP2/3up-regulates img/indirect-activation.png F-actin_assembly 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-251511 Homo sapiens
pmid sentence
The Arp2/3 complex concentrates at leading edges, where it catalyzes the growth of branched actin networks that are believed to provide the protrusive force for leading edge extension.
Publications: 1 Organism: Homo Sapiens
Pathways:T cell activation
+ ARPC3form complex img/form-complex.png binding ARP2/3 0.964
Identifier Residue Sequence Organism Cell Line
SIGNOR-251516 Homo sapiens
pmid sentence
The subunits in mammalian cells are named Arp3, Arp2, p41-Arc, p34-Arc, p21-Arc, p20-Arc and p16-Arc
Publications: 1 Organism: Homo Sapiens
+ ARPC2form complex img/form-complex.png binding ARP2/3 0.96
Identifier Residue Sequence Organism Cell Line
SIGNOR-251514 Homo sapiens
pmid sentence
The subunits in mammalian cells are named Arp3, Arp2, p41-Arc, p34-Arc, p21-Arc, p20-Arc and p16-Arc
Publications: 1 Organism: Homo Sapiens
+ ARPC4form complex img/form-complex.png binding ARP2/3 0.965
Identifier Residue Sequence Organism Cell Line
SIGNOR-251517 Homo sapiens
pmid sentence
The subunits in mammalian cells are named Arp3, Arp2, p41-Arc, p34-Arc, p21-Arc, p20-Arc and p16-Arc
Publications: 1 Organism: Homo Sapiens
+ JMYup-regulates activity img/direct-activation.png binding ARP2/3 0.311
Identifier Residue Sequence Organism Cell Line
SIGNOR-261005 Homo sapiens HeLa Cell
pmid sentence
Members of the Wiskott-Aldrich syndrome protein (WASP) family, which includes WASP, N-WASP, WAVE (1–3), WHAMM, JMY, and WASH, control actin cytoskeletal dynamics throughout biology. They act in large part by regulating the actin nucleating activity of the ubiquitous Arp2/3 complex. WASP proteins stimulate Arp2/3 complex using a conserved C-terminal VCA (Verprolin homologous, central hydrophobic, and acidic) region. They contain distinct N-terminal elements, which facilitate integration into unique macromolecular complexes.
Publications: 1 Organism: Homo Sapiens
+ ACTR2form complex img/form-complex.png binding ARP2/3 0.929
Identifier Residue Sequence Organism Cell Line
SIGNOR-251512 Homo sapiens
pmid sentence
The subunits in mammalian cells are named Arp3, Arp2, p41-Arc, p34-Arc, p21-Arc, p20-Arc and p16-Arc
Publications: 1 Organism: Homo Sapiens
+ WASLup-regulates activity img/direct-activation.png binding ARP2/3 0.788
Identifier Residue Sequence Organism Cell Line
SIGNOR-261003 Homo sapiens HeLa Cell
pmid sentence
Members of the Wiskott-Aldrich syndrome protein (WASP) family, which includes WASP, N-WASP, WAVE (1–3), WHAMM, JMY, and WASH, control actin cytoskeletal dynamics throughout biology. They act in large part by regulating the actin nucleating activity of the ubiquitous Arp2/3 complex. WASP proteins stimulate Arp2/3 complex using a conserved C-terminal VCA (Verprolin homologous, central hydrophobic, and acidic) region. They contain distinct N-terminal elements, which facilitate integration into unique macromolecular complexes.
Publications: 1 Organism: Homo Sapiens
+ WHAMMup-regulates activity img/direct-activation.png binding ARP2/3 0.351
Identifier Residue Sequence Organism Cell Line
SIGNOR-261004 Homo sapiens HeLa Cell
pmid sentence
Members of the Wiskott-Aldrich syndrome protein (WASP) family, which includes WASP, N-WASP, WAVE (1–3), WHAMM, JMY, and WASH, control actin cytoskeletal dynamics throughout biology. They act in large part by regulating the actin nucleating activity of the ubiquitous Arp2/3 complex. WASP proteins stimulate Arp2/3 complex using a conserved C-terminal VCA (Verprolin homologous, central hydrophobic, and acidic) region. They contain distinct N-terminal elements, which facilitate integration into unique macromolecular complexes.
Publications: 1 Organism: Homo Sapiens
+ ARPC5form complex img/form-complex.png binding ARP2/3 0.96
Identifier Residue Sequence Organism Cell Line
SIGNOR-251518 Homo sapiens
pmid sentence
The subunits in mammalian cells are named Arp3, Arp2, p41-Arc, p34-Arc, p21-Arc, p20-Arc and p16-Arc
Publications: 1 Organism: Homo Sapiens
+ DNM1Lup-regulates activity img/direct-activation.png binding ARP2/3 0.284
Identifier Residue Sequence Organism Cell Line
SIGNOR-262550 Mus musculus Podocyte
pmid sentence
Importantly, we found that crosstalk between phosphorylated Drp1S600 (p-Drp1S600) and the actin-binding protein com- plex Arp2/3 is a required step in mitochondrial Drp1 recruitment and mitochondrial fission under HG conditions.
Publications: 1 Organism: Mus Musculus
+ WASH complexup-regulates activity img/direct-activation.png binding ARP2/3 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-261006 Homo sapiens HeLa Cell
pmid sentence
Members of the Wiskott-Aldrich syndrome protein (WASP) family, which includes WASP, N-WASP, WAVE (1–3), WHAMM, JMY, and WASH, control actin cytoskeletal dynamics throughout biology. They act in large part by regulating the actin nucleating activity of the ubiquitous Arp2/3 complex. WASP proteins stimulate Arp2/3 complex using a conserved C-terminal VCA (Verprolin homologous, central hydrophobic, and acidic) region. They contain distinct N-terminal elements, which facilitate integration into unique macromolecular complexes.
Publications: 1 Organism: Homo Sapiens
+ WASup-regulates activity img/direct-activation.png binding ARP2/3 0.81
Identifier Residue Sequence Organism Cell Line
SIGNOR-261001 Homo sapiens HeLa Cell
pmid sentence
Members of the Wiskott-Aldrich syndrome protein (WASP) family, which includes WASP, N-WASP, WAVE (1–3), WHAMM, JMY, and WASH, control actin cytoskeletal dynamics throughout biology. They act in large part by regulating the actin nucleating activity of the ubiquitous Arp2/3 complex. WASP proteins stimulate Arp2/3 complex using a conserved C-terminal VCA (Verprolin homologous, central hydrophobic, and acidic) region. They contain distinct N-terminal elements, which facilitate integration into unique macromolecular complexes.
Publications: 1 Organism: Homo Sapiens
Pathways:T cell activation
+ WAVE complexup-regulates activity img/direct-activation.png binding ARP2/3 0.544
Identifier Residue Sequence Organism Cell Line
SIGNOR-261876 Homo sapiens Blood Platelet
pmid sentence
Cdc42 can induce Arp2/3-mediated filopodia formation through the activation of WASp (Wiskott-Aldrich syndrome proteins) and neuronal N-WASp (Rohatgi et al., 1999). Similarly, Rac1-enhanced lamellipodia formation is related to Arp2/3 activation by the WAVE (WASP-family verprolin-homologous) complex
Publications: 1 Organism: Homo Sapiens
+ ARP2/3up-regulates quantity img/direct-activation.png binding F-actin_assembly 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-261838 Homo sapiens Blood Platelet
pmid sentence
The Arp2/3 complex stimulates the assembly of actin filaments.
Publications: 1 Organism: Homo Sapiens
Pathways:T cell activation
+ NHSup-regulates activity img/direct-activation.png relocalization ARP2/3 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-253566 Homo sapiens
pmid sentence
NHS knockdown also resulted in the mislocalization of the Arp2/3 complex and disruption of the actin cytoskeleton. in the absence of NHS, Arp2/3 localization and F-actin distribution are disrupted, suggesting that Arp2/3 actin-nucleation activity is mediated, in part, by NHS providing an additional functional link between NHS and actin.
Publications: 1 Organism: Homo Sapiens
+ ACTR3form complex img/form-complex.png binding ARP2/3 0.919
Identifier Residue Sequence Organism Cell Line
SIGNOR-251513 Homo sapiens
pmid sentence
The subunits in mammalian cells are named Arp3, Arp2, p41-Arc, p34-Arc, p21-Arc, p20-Arc and p16-Arc
Publications: 1 Organism: Homo Sapiens
+ ARPC1Aform complex img/form-complex.png binding ARP2/3 0.876
Identifier Residue Sequence Organism Cell Line
SIGNOR-251515 Homo sapiens
pmid sentence
The subunits in mammalian cells are named Arp3, Arp2, p41-Arc, p34-Arc, p21-Arc, p20-Arc and p16-Arc
Publications: 1 Organism: Homo Sapiens
+ CTTNup-regulates activity img/direct-activation.png binding ARP2/3 0.645
Identifier Residue Sequence Organism Cell Line
SIGNOR-251519 Homo sapiens
pmid sentence
Cortactin binds directly to the Arp2/3 complex and activates it to promote nucleation of actin filaments.
Publications: 1 Organism: Homo Sapiens
Pathways:T cell activation
+ WRC complexup-regulates activity img/direct-activation.png binding ARP2/3 0.542
Identifier Residue Sequence Organism Cell Line
SIGNOR-253573 Homo sapiens
pmid sentence
The activated WAVE complex at the leading edge of lamellipodia promotes actin polymerization at the plasma membrane by activating the Arp2/3 complex
Publications: 1 Organism: Homo Sapiens
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