| + |
WAS | up-regulates activity 
binding
|
ARP2/3 |
0.803 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261001 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 20498093 |
Members of the Wiskott-Aldrich syndrome protein (WASP) family, which includes WASP, N-WASP, WAVE (1–3), WHAMM, JMY, and WASH, control actin cytoskeletal dynamics throughout biology. They act in large part by regulating the actin nucleating activity of the ubiquitous Arp2/3 complex. WASP proteins stimulate Arp2/3 complex using a conserved C-terminal VCA (Verprolin homologous, central hydrophobic, and acidic) region. They contain distinct N-terminal elements, which facilitate integration into unique macromolecular complexes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | T cell activation |
| + |
ACTR2 | form complex 
binding
|
ARP2/3 |
0.924 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251512 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12479800 |
The subunits in mammalian cells are named Arp3, Arp2, p41-Arc, p34-Arc, p21-Arc, p20-Arc and p16-Arc |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ARPC2 | form complex
binding
|
ARP2/3 |
0.957 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251514 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12479800 |
The subunits in mammalian cells are named Arp3, Arp2, p41-Arc, p34-Arc, p21-Arc, p20-Arc and p16-Arc |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ARPC5 | form complex
binding
|
ARP2/3 |
0.958 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251518 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12479800 |
The subunits in mammalian cells are named Arp3, Arp2, p41-Arc, p34-Arc, p21-Arc, p20-Arc and p16-Arc |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ARPC1A | form complex
binding
|
ARP2/3 |
0.869 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251515 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12479800 |
The subunits in mammalian cells are named Arp3, Arp2, p41-Arc, p34-Arc, p21-Arc, p20-Arc and p16-Arc |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ARP2/3 | up-regulates quantity
binding
|
F-actin_assembly |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261838 |
|
|
Homo sapiens |
Blood Platelet |
| pmid |
sentence |
| 27871158 |
The Arp2/3 complex stimulates the assembly of actin filaments. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | T cell activation |
| + |
ARPC4 | form complex
binding
|
ARP2/3 |
0.963 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251517 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12479800 |
The subunits in mammalian cells are named Arp3, Arp2, p41-Arc, p34-Arc, p21-Arc, p20-Arc and p16-Arc |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
WHAMM | up-regulates activity
binding
|
ARP2/3 |
0.362 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261004 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 20498093 |
Members of the Wiskott-Aldrich syndrome protein (WASP) family, which includes WASP, N-WASP, WAVE (1–3), WHAMM, JMY, and WASH, control actin cytoskeletal dynamics throughout biology. They act in large part by regulating the actin nucleating activity of the ubiquitous Arp2/3 complex. WASP proteins stimulate Arp2/3 complex using a conserved C-terminal VCA (Verprolin homologous, central hydrophobic, and acidic) region. They contain distinct N-terminal elements, which facilitate integration into unique macromolecular complexes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ACTR3 | form complex
binding
|
ARP2/3 |
0.913 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251513 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12479800 |
The subunits in mammalian cells are named Arp3, Arp2, p41-Arc, p34-Arc, p21-Arc, p20-Arc and p16-Arc |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NHS | up-regulates activity
relocalization
|
ARP2/3 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253566 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20332100 |
NHS knockdown also resulted in the mislocalization of the Arp2/3 complex and disruption of the actin cytoskeleton. in the absence of NHS, Arp2/3 localization and F-actin distribution are disrupted, suggesting that Arp2/3 actin-nucleation activity is mediated, in part, by NHS providing an additional functional link between NHS and actin. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
WRC complex | up-regulates activity
binding
|
ARP2/3 |
0.523 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253573 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20332100 |
The activated WAVE complex at the leading edge of lamellipodia promotes actin polymerization at the plasma membrane by activating the Arp2/3 complex |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ARPC3 | form complex
binding
|
ARP2/3 |
0.962 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251516 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12479800 |
The subunits in mammalian cells are named Arp3, Arp2, p41-Arc, p34-Arc, p21-Arc, p20-Arc and p16-Arc |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
WASL | up-regulates activity
binding
|
ARP2/3 |
0.78 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261003 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 20498093 |
Members of the Wiskott-Aldrich syndrome protein (WASP) family, which includes WASP, N-WASP, WAVE (1–3), WHAMM, JMY, and WASH, control actin cytoskeletal dynamics throughout biology. They act in large part by regulating the actin nucleating activity of the ubiquitous Arp2/3 complex. WASP proteins stimulate Arp2/3 complex using a conserved C-terminal VCA (Verprolin homologous, central hydrophobic, and acidic) region. They contain distinct N-terminal elements, which facilitate integration into unique macromolecular complexes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CTTN | up-regulates activity
binding
|
ARP2/3 |
0.63 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251519 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11231575 |
Cortactin binds directly to the Arp2/3 complex and activates it to promote nucleation of actin filaments. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | T cell activation |
| + |
ARP2/3 | up-regulates 
|
F-actin_assembly |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251511 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12479800 |
The Arp2/3 complex concentrates at leading edges, where it catalyzes the growth of branched actin networks that are believed to provide the protrusive force for leading edge extension. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | T cell activation |
| + |
DNM1L | up-regulates activity
binding
|
ARP2/3 |
0.289 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-262550 |
|
|
Mus musculus |
Podocyte |
| pmid |
sentence |
| 31063459 |
Importantly, we found that crosstalk between phosphorylated Drp1S600 (p-Drp1S600) and the actin-binding protein com- plex Arp2/3 is a required step in mitochondrial Drp1 recruitment and mitochondrial fission under HG conditions. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
WASH complex | up-regulates activity
binding
|
ARP2/3 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261006 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 20498093 |
Members of the Wiskott-Aldrich syndrome protein (WASP) family, which includes WASP, N-WASP, WAVE (1–3), WHAMM, JMY, and WASH, control actin cytoskeletal dynamics throughout biology. They act in large part by regulating the actin nucleating activity of the ubiquitous Arp2/3 complex. WASP proteins stimulate Arp2/3 complex using a conserved C-terminal VCA (Verprolin homologous, central hydrophobic, and acidic) region. They contain distinct N-terminal elements, which facilitate integration into unique macromolecular complexes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
WAVE complex | up-regulates activity
binding
|
ARP2/3 |
0.525 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261876 |
|
|
Homo sapiens |
Blood Platelet |
| pmid |
sentence |
| 27871158 |
Cdc42 can induce Arp2/3-mediated filopodia formation through the activation of WASp (Wiskott-Aldrich syndrome proteins) and neuronal N-WASp (Rohatgi et al., 1999). Similarly, Rac1-enhanced lamellipodia formation is related to Arp2/3 activation by the WAVE (WASP-family verprolin-homologous) complex |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
JMY | up-regulates activity
binding
|
ARP2/3 |
0.319 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261005 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 20498093 |
Members of the Wiskott-Aldrich syndrome protein (WASP) family, which includes WASP, N-WASP, WAVE (1–3), WHAMM, JMY, and WASH, control actin cytoskeletal dynamics throughout biology. They act in large part by regulating the actin nucleating activity of the ubiquitous Arp2/3 complex. WASP proteins stimulate Arp2/3 complex using a conserved C-terminal VCA (Verprolin homologous, central hydrophobic, and acidic) region. They contain distinct N-terminal elements, which facilitate integration into unique macromolecular complexes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
ARP2/3
CPX-2586