+ |
EPHB6 | down-regulates activity
binding
|
EPHA2 |
0.397 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-273853 |
|
|
Homo sapiens |
MCF-7 Cell |
pmid |
sentence |
25239188 |
EphB6 is frequently silenced in invasive and metastatic cancers; however, its role in cancer progression is poorly understood. Here we show that EphB6 interacts with EphA2 and suppresses EphA2-mediated promotion of anoikis resistance in MCF7 breast cancer cells. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
EPHB6 | up-regulates activity
binding
|
CBLC |
0.276 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-273852 |
|
|
Homo sapiens |
|
pmid |
sentence |
34360976 |
We suggest that although mammalian EphB6 is kinase-negative, it has retained the allosteric regulatory mechanisms involving the juxtamembrane and the SAM domain linker that are used to regulate the kinase activity of kinase-active Eph receptors. he inability to recruit c-Cbl by EphB6 meant that heightened levels of EphA2 remained active in the cell because they had evaded c-Cbl-mediated degradation. The authors suggest that mutation of residues 901–926 within EphB6 reduces the flexibility of the SAM domain such that c-Cbl cannot be recruited. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |