| + |
PRKN | down-regulates quantity by destabilization 
ubiquitination
|
GPR37 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249706 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12666095 |
Parkin is a protein of 465 amino acids, and its structure includes a ubiquitin homologous domain in its N terminus and two RING finger domains in its C terminus. Molecular studies have determined that parkin is an E3 ubiquitin ligase function, implicating parkin in the ubiquitin-proteasome system, and raising the possibility that mutations in the gene lead to loss or diminished function. Three substrates for the ubiquitin-ligase function of parkin have been identified to date.1. A 22kDa glycosolated form of alpha-synuclei|2. Parkin-associated endothelin receptor-like receptor (Pael-R). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SYVN1 | down-regulates quantity by destabilization
polyubiquitination
|
GPR37 |
0.409 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-272631 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18241051 |
We demonstrated that endogenous HRD1 interacts with Pael-R, and that HRD1 promotes the degradation of Pael-R and protects cell death caused by the accumulation of Pael-R. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
GPR37 | up-regulates 
|
ER stress |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249701 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12666095 |
Parkin-associated endothelin receptor-like receptor (Pael-R). Overexpression of this protein causes it to become ubiquinated, insoluble, and unfolded, leading to endoplasmic reticulum stress and cell death. Furthermore, an insoluble form of Pael-R has been demonstrated to accumulate in the brains of patients with Parkin mutations, suggesting a possible toxic mechanism. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
GPR37
- 
- 