Summary

Name GRIN2D
Full Name Glutamate receptor ionotropic, NMDA 2D
Synonyms GluN2D, EB11, Glutamate [NMDA] receptor subunit epsilon-4, N-methyl D-aspartate receptor subtype 2D, NMDAR2D, NR2D | GluN2D, NMDAR2D
Primary ID O15399
Links - -
Type protein
Relations 1
Function Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+) (PubMed:9489750, PubMed:27616483, PubMed:26875626, PubMed:28126851). Sensitivity to glutamate and channel kinetics depend on the subunit composition (PubMed:9489750).

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Relations

Regulator Mechanism target score
+ form complex img/form-complex.png binding NMDA receptor_2D 0.644
Publications: 1 Organism: Homo Sapiens