| + |
NMDA receptor_2D | up-regulates 
|
Excitatory_synaptic_transmission |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264135 |
|
|
Homo sapiens |
Neuron |
| pmid |
sentence |
| 24564659 |
Excitatory synaptic transmission in the mammalian brain is mediated primarily by the amino acid glutamate, activating two different groups of glutamate receptors: ionotropic and metabotropic. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NMDA receptor_2D | up-regulates activity 
binding
|
DLG4 |
0.731 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264225 |
|
|
Homo sapiens |
Neuron |
| pmid |
sentence |
| 11052931 |
Another central component of the NMDA receptor signaling complex is the scaffold protein PSD-95 (also referred to as SAP-90). The first and second PDZ domains bind tightly to the tails of the NR2 subunits of the NMDA receptor |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NMDA receptor_2D | up-regulates activity
binding
|
CAMK2A |
0.566 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264217 |
|
|
Homo sapiens |
Neuron |
| pmid |
sentence |
| 11052931 |
The most abundant signaling protein in the PSD fraction is Ca2+/calmodulin–dependent protein kinase II (CaMKII), which makes up 1 to 2% of the total protein in the forebrain (21). CaMKII is a target for Ca2+ flowing through the NMDA receptor and is necessary for normal synaptic plasticity in pyramidal neurons. The cytosolic tails of the NR2 subunits of the NMDA receptor bind to CaMKII and thus can serve as docking sites for it in the PSD |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NMDA receptor_2D | up-regulates quantity
relocalization
|
CTTN |
0.292 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266602 |
|
|
Homo sapiens |
Brain |
| pmid |
sentence |
| 14684878 |
Here we show that cortactin is concentrated with F-actin in dendritic spines of cultured hippocampal neurons but is redistributed to the dendritic shaft in response to NMDA receptor activation. these findings indicate that the translocation of cortactin is induced by the activation of NMDA receptors. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
D-serine | up-regulates activity
chemical activation
|
NMDA receptor_2D |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268280 |
|
|
Homo sapiens |
Astroglial Cell |
| pmid |
sentence |
| 12393813 |
D-serine acts in concert with L-glutamate (triangles) to activate NMDA receptors|D-serine released from astrocytes seems to be an endogenous ligand of the N-methyl-D-aspartate (NMDA) receptor (3, 8). Depletion of endogenous D-serine in slices and cultured cells strongly diminishes NMDA receptor responses measured biochemically and electrophysiologically |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
DLG3 | up-regulates activity
relocalization
|
NMDA receptor_2D |
0.633 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266009 |
|
|
|
|
| pmid |
sentence |
| 32904533 |
DLG3 plays a critical role in clustering of NMDA receptors at excitatory synapses. |
|
| Publications: |
1 |
| Tissue: |
Central Nervous System |
| + |
GRIN1 | form complex 
binding
|
NMDA receptor_2D |
0.649 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264126 |
|
|
Homo sapiens |
Neuron |
| pmid |
sentence |
| 12871085 |
The NMDA receptor, a ligand-gated ion channel composed of the NR1 and NR2 subunits, is located mainly at synapses of CNS neurons. The NMDA receptor subtypes are encoded by three gene families that process mRNA transcripts to yield six distinct subunits (NR1, NR2A-2D, NR3A). Receptors are thought to be tetrameric complexes of two NR1 and two NR2 subunits |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
glutamic acid | up-regulates activity
chemical activation
|
NMDA receptor_2D |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264131 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12871085 |
The NMDA receptor, a ligand-gated ion channel composed of the NR1 and NR2 subunits, is located mainly at synapses of CNS neurons. Each receptor has two binding sites for glycine and two binding sites for glutamate |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
GRIN2D | form complex
binding
|
NMDA receptor_2D |
0.649 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264127 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12871085 |
The NMDA receptor, a ligand-gated ion channel composed of the NR1 and NR2 subunits, is located mainly at synapses of CNS neurons. The NMDA receptor subtypes are encoded by three gene families that process mRNA transcripts to yield six distinct subunits (NR1, NR2A-2D, NR3A). Receptors are thought to be tetrameric complexes of two NR1 and two NR2 subunits |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NMDA receptor_2D | up-regulates quantity
relocalization
|
calcium(2+) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264221 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 30037851 |
NMDA-type glutamate receptors are ligand-gated ion channels that mediate a Ca2+-permeable component of excitatory neurotransmission in the central nervous system (CNS). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
NMDA receptor_2D
CPX-289