4.0
Summary
| Name |  MAFGView Modifications |
| Full Name | Transcription factor MafG |
| Synonyms | V-maf musculoaponeurotic fibrosarcoma oncogene homolog G, hMAF |
| Primary ID | O15525 |
| Links |  -  -  |
| Type | protein |
| Relations | 3 |
| Function | Since they lack a putative transactivation domain, the small Mafs behave as transcriptional repressors when they dimerize among themselves (PubMed:11154691). However, they seem to serve as transcriptional activators by dimerizing with other (usually larger) basic-zipper proteins, such as NFE2, NFE2L1 and NFE2L2, and recruiting them to specific DNA-binding sites (PubMed:8932385, PubMed:9421508, PubMed:11154691). Small Maf proteins heterodimerize with Fos and may act as competitive repressors of the NFE2L2 transcription factor (PubMed:11154691). Transcription factor, component of erythroid-specific transcription factor NFE2L2 (PubMed:11154691). Activates globin gene expression when associated with NFE2L2 (PubMed:11154691). May be involved in signal transduction of extracellular H(+) (By similarity). |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | MAPK3 | up-regulates quantity 
phosphorylation
|
MAFG | |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | HOXD12 | down-regulates activity 
binding
|
MAFG | 0.375 |
| Publications: | 1 | Organism: | In Vitro | |
| + | PRRX1 | down-regulates activity
binding
|
MAFG | 0.338 |
| Publications: | 1 | Organism: | In Vitro | |