Summary

Name CYP26A1
Full Name Cytochrome P450 26A1
Synonyms Cytochrome P450 retinoic acid-inactivating 1, Cytochrome P450RAI, hP450RAI, Retinoic acid 4-hydroxylase, Retinoic acid-metabolizing cytochrome | CYP26, P450RAI1
Primary ID O43174
Links - -
Type protein
Relations 3
Pathways Retinoic Acid Metabolism
Inhibitors CYP26A1
Function A cytochrome P450 monooxygenase involved in the metabolism of all-trans retinoic acid (atRA), a signaling molecule that binds to retinoic acid receptors and regulates gene transcription. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Catalyzes the hydroxylation of carbon hydrogen bonds of atRA primarily at C-4 and C-18. Has no activity toward 9-cis and 13-cis retinoic acid stereoisomers (PubMed:22020119, PubMed:9228017, PubMed:9716180). May play a role in the oxidative metabolism of xenobiotics such as tazarotenic acid (PubMed:26937021).

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Relations

Regulator Mechanism target score ℹ
+ all-trans-retinoic acidup-regulates activity img/direct-activation.png chemical activation CYP26A1 0.8
Publications: 1 Organism: Homo Sapiens
Pathways:Retinoic Acid Metabolism
+ CYP26A1down-regulates activity img/direct_inhibition.png chemical inhibition all-trans-retinoic acid 0.8
Publications: 1 Organism: Homo Sapiens
Pathways:Retinoic Acid Metabolism
+ CYP26A1down-regulates quantity img/direct_inhibition.png chemical modification all-trans-retinoic acid 0.8
Publications: 1 Organism: Homo Sapiens
Pathways:Retinoic Acid Metabolism