| + |
KCNQ3 | up-regulates quantity 
relocalization
|
potassium(1+) |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265984 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19298256 |
KCNQ genes encode five Kv7 K+ channel subunits (Kv7.1–Kv7.5). Four of these (Kv7.2–Kv7.5) are expressed in the nervous system. Kv7.2 and Kv7.3 are the principal molecular components of the slow voltage-gated M-channel, which widely regulates neuronal excitability, although other subunits may contribute to M-like currents in some locations. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
KCNQ3 | up-regulates activity
binding
|
KCNQ2 |
0.492 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268832 |
|
|
Rattus norvegicus |
Neuron |
| pmid |
sentence |
| 9836639 |
The M-current regulates the subthreshold electrical excitability of many neurons, determining their firing properties and responsiveness to synaptic input. To date, however, the genes that encode subunits of this important channel have not been identified. The biophysical properties, sensitivity to pharmacological blockade, and expression pattern of the KCNQ2 and KCNQ3 potassium channels were determined. It is concluded that both these subunits contribute to the native M-current. |
|
| Publications: |
1 |
Organism: |
Rattus Norvegicus |
| + |
ezogabine | up-regulates
chemical activation
|
KCNQ3 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-206541 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| Other |
|
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
KCNQ2 | up-regulates activity
binding
|
KCNQ3 |
0.492 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268833 |
|
|
Rattus norvegicus |
Neuron |
| pmid |
sentence |
| 9836639 |
The M-current regulates the subthreshold electrical excitability of many neurons, determining their firing properties and responsiveness to synaptic input. To date, however, the genes that encode subunits of this important channel have not been identified. The biophysical properties, sensitivity to pharmacological blockade, and expression pattern of the KCNQ2 and KCNQ3 potassium channels were determined. It is concluded that both these subunits contribute to the native M-current. |
|
| Publications: |
1 |
Organism: |
Rattus Norvegicus |
3.0
KCNQ3
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- 