Summary

Name KCNQ2
Full Name Potassium voltage-gated channel subfamily KQT member 2
Synonyms KQT-like 2, Neuroblastoma-specific potassium channel subunit alpha KvLQT2, Voltage-gated potassium channel subunit Kv7.2
Primary ID O43526
Links - -
Type protein
Relations 6
Function Associates with KCNQ3 to form a potassium channel with essentially identical properties to the channel underlying the native M-current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons as well as the responsiveness to synaptic inputs. Therefore, it is important in the regulation of neuronal excitability. KCNQ2/KCNQ3 current is blocked by linopirdine and XE991, and activated by the anticonvulsant retigabine (PubMed:9836639, PubMed:11572947, PubMed:14534157, PubMed:12742592, PubMed:17872363). As the native M-channel, the potassium channel composed of KCNQ2 and KCNQ3 is also suppressed by activation of the muscarinic acetylcholine receptor CHRM1 (PubMed:10684873).

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▶Modifications Tables

Relations

Regulator Mechanism target score ℹ
+ PRKCAup-regulates activity img/direct-activation.png phosphorylation KCNQ2 0.329
Publications: 1 Organism: Cricetulus Griseus
+ PRKCAup-regulates quantity img/direct-activation.png phosphorylation KCNQ2 0.329
Publications: 1 Organism: Cricetulus Griseus
+ KCNQ2up-regulates activity img/direct-activation.png binding KCNQ3 0.497
Publications: 1 Organism: Rattus Norvegicus
+ KCNQ2up-regulates quantity img/direct-activation.png relocalization potassium(1+) 0.8
Publications: 1 Organism: Homo Sapiens
+ KCNQ3up-regulates activity img/direct-activation.png binding KCNQ2 0.497
Publications: 1 Organism: Rattus Norvegicus
+ ezogabineup-regulates img/direct-activation.png chemical activation KCNQ2 0.8
Publications: 1 Organism: Homo Sapiens