Summary

Name CHD8
Full Name Chromodomain-helicase-DNA-binding protein 8
Synonyms CHD-8, ATP-dependent helicase CHD8, Helicase with SNF2 domain 1 | HELSNF1, KIAA1564
Primary ID Q9HCK8
Links - -
Type protein
Relations 15
Function DNA helicase that acts as a chromatin remodeling factor and regulates transcription. Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive genes. Involved in both enhancer blocking and epigenetic remodeling at chromatin boundary via its interaction with CTCF. Acts as a suppressor of STAT3 activity by suppressing the LIF-induced STAT3 transcriptional activity. Also acts as a transcription activator via its interaction with ZNF143 by participating in efficient U6 RNA polymerase III transcription.

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Relations

Regulator Mechanism target score
+ down-regulates quantity img/direct_inhibition.png transcriptional regulation MAP2 0.2
Publications: 1 Organism: Mus Musculus
+ down-regulates quantity img/direct_inhibition.png transcriptional regulation SOX7 0.2
Publications: 1 Organism: Mus Musculus
+ up-regulates activity img/direct-activation.png binding RNA Polymerase II 0.282
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity img/direct_inhibition.png transcriptional regulation DCX 0.2
Publications: 1 Organism: Mus Musculus
+ down-regulates img/direct_inhibition.png binding CTNNB1 0.626
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity img/direct_inhibition.png transcriptional regulation SOX11 0.2
Publications: 1 Organism: Mus Musculus
+ up-regulates activity img/direct-activation.png binding MLL/SET subcomplex 0.426
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity img/direct_inhibition.png transcriptional regulation NEUROD4 0.2
Publications: 1 Organism: Mus Musculus
+ down-regulates quantity img/direct_inhibition.png transcriptional regulation NEUROG1 0.2
Publications: 1 Organism: Mus Musculus
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation CCNE2 0.423
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity img/direct_inhibition.png transcriptional regulation SOX2 0.322
Publications: 1 Organism: Mus Musculus
+ down-regulates quantity img/direct_inhibition.png transcriptional regulation NEFM 0.2
Publications: 1 Organism: Mus Musculus
+ down-regulates quantity img/direct_inhibition.png transcriptional regulation SOX3 0.2
Publications: 1 Organism: Mus Musculus
+ down-regulates quantity img/direct_inhibition.png transcriptional regulation ASCL1 0.2
Publications: 1 Organism: Mus Musculus
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation TYMS 0.284
Publications: 1 Organism: Homo Sapiens