Summary

Name SPRY1
Full Name Protein sprouty homolog 1
Synonyms Spry-1
Primary ID O43609
Links - -
Type protein
Relations 2
Pathways Noonan syndrome
Function Inhibits fibroblast growth factor (FGF)-induced retinal lens fiber differentiation, probably by inhibiting FGF-mediated phosphorylation of ERK1/2 (By similarity). Inhibits TGFB-induced epithelial-to-mesenchymal transition in lens epithelial cells (By similarity).

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Relations

Regulator Mechanism target score ℹ
+ PTPN11down-regulates img/direct_inhibition.png dephosphorylation SPRY1 0.419
Publications: 1 Organism: Homo Sapiens
Pathways:Noonan syndrome
+ SPRY1down-regulates img/direct_inhibition.png binding SOS1 0.395
Publications: 1 Organism: Homo Sapiens
Pathways:Noonan syndrome