Summary

Name HCRT
Full Name Orexin
Synonyms Hypocretin, Hcrt | OX, PPORX, PPOX
Primary ID O43612
Links - -
Type protein
Relations 2
Function Neuropeptides that play a significant role in the regulation of food intake and sleep-wakefulness, possibly by coordinating the complex behavioral and physiologic responses of these complementary homeostatic functions. A broader role in the homeostatic regulation of energy metabolism, autonomic function, hormonal balance and the regulation of body fluids, is also suggested. Orexin-A binds to both OX1R and OX2R with a high affinity, whereas orexin-B binds only to OX2R with a similar high affinity.

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Relations

Regulator Mechanism target score
+ up-regulates img/direct-activation.png binding HCRTR1 0.765
Publications: 1 Organism: Homo Sapiens
Tissue: Brain
+ up-regulates img/direct-activation.png binding HCRTR2 0.768
Publications: 1 Organism: Homo Sapiens