Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-259098 |
|
|
Homo sapiens |
T-lymphoblastic Leukemia Cell Line |
pmid |
sentence |
22516263 |
We show that the cortical thymic maturation arrest in T-lineage ALLs that overexpress TLX1 or TLX3 is due to binding of TLX1/TLX3 to ETS1, leading to repression of T cell receptor (TCR) α enhanceosome activity and blocked TCR-Jα rearrangement. |
|