| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267564 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 32808929 |
The dynamic nature of the human origin recognition complex revealed through five cryoEM structures|Genome replication is initiated from specific origin sites established by dynamic events. The Origin Recognition Complex (ORC) is necessary for orchestrating the initiation process by binding to origin DNA, recruiting CDC6, and assembling the MCM replicative helicase on DNA. Here we report five cryoEM structures of the human ORC (HsORC) that illustrate the native flexibility of the complex. |The very first step of this initiation process is accomplished by DNA association with the Origin Recognition Complex (ORC), a six-subunit protein that forms a partial ring around origin DNA |
|
3.0
ORC4
- 
- 
binding