+ |
MAPKAPK5 | up-regulates activity
phosphorylation
|
KALRN |
0.357 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-263093 |
Ser487 |
DVLQRPLsPGNSESL |
in vitro |
|
pmid |
sentence |
22508986 |
The brain-specific nucleotide exchange factor kalirin-7 (Kal7) was identified as an MK5 interaction partner and substrate protein. The MK5 substrate Kal7, a Rho GEF and known activator of Rac GTPases, further contributes to PAK activation and actin filament reorganization. Thus, the coordinated phosphorylation of Borg proteins and Kal7 by ERK3 and MK5 constitute a novel signaling cascade involving feed-forward circuits, multiple GTPases, and cytoskeletal elements. The fragment SR3-6, but not the mutated fragment SR3-6-S487A, is phosphorylated by MK5. |
|
Publications: |
1 |
Organism: |
In Vitro |
+ |
MAPK6 | up-regulates activity
phosphorylation
|
KALRN |
0.38 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-263094 |
|
|
in vitro |
|
pmid |
sentence |
22508986 |
The brain-specific nucleotide exchange factor kalirin-7 (Kal7) was identified as an MK5 interaction partner and substrate protein. The MK5 substrate Kal7, a Rho GEF and known activator of Rac GTPases, further contributes to PAK activation and actin filament reorganization. Thus, the coordinated phosphorylation of Borg proteins and Kal7 by ERK3 and MK5 constitute a novel signaling cascade involving feed-forward circuits, multiple GTPases, and cytoskeletal elements. |
|
Publications: |
1 |
Organism: |
In Vitro |