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Summary
Name
PPP1R12B
View Modifications
Full Name
Protein phosphatase 1 regulatory subunit 12B
Synonyms
Myosin phosphatase-targeting subunit 2, Myosin phosphatase target subunit 2 | MYPT2
Primary ID
O60237
Links
-
-
Type
protein
Relations
1
Function
Regulates myosin phosphatase activity. Augments Ca(2+) sensitivity of the contractile apparatus.
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by mechanism
none
phosphorylation
by effect
none
down-regulates
by organism:
none
Homo sapiens
by tissue:
none
by cell-line
none
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Modifications Tables
PPP1R12B as Target
Residue
Sequence
Modifier
Effect
Modification
Thr646
ARQTRRStQGVTLTD
ROCK1
inhibition
phosphorylation
Relations
Regulator
Mechanism
target
score
ℹ
+
ROCK1
down-regulates
phosphorylation
PPP1R12B
0.569
Identifier
Residue
Sequence
Organism
Cell Line
SIGNOR-198812
Thr646
ARQTRRStQGVTLTD
Homo sapiens
pmid
sentence
22937917
Phosphorylation of ppp1r12b on threonine 646 by rho kinase inhibits the activity of the pp1c-ppp1r12b complex.
Publications:
1
Organism:
Homo Sapiens