+ |
CAMK2G | down-regulates activity
phosphorylation
|
ADCY3 |
0.358 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-250691 |
Ser1076 |
NVASRMEsTGVMGNI |
Homo sapiens |
HEK-293 Cell |
pmid |
sentence |
8798667 |
Phosphorylation and inhibition of type III adenylyl cyclase by calmodulin-dependent protein kinase II in vivo. | Site-directed mutagenesis of a CaM kinase II consensus site (Ser-1076 to Ala-1076) in III-AC greatly reduced Ca2+-stimulated phosphorylation and inhibition of III-AC in vivo. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
ADCY3 | up-regulates quantity
chemical modification
|
3',5'-cyclic AMP |
0.8 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-265000 |
|
|
Homo sapiens |
|
pmid |
sentence |
15385642 |
Adenylyl cyclases (AC), a family of enzymes that catalyze the synthesis of cyclic AMP, are critical regulators of cellular functions. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
GNAL | up-regulates activity
binding
|
ADCY3 |
0.631 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-278072 |
|
|
Homo sapiens |
Entorhinal Cortex |
pmid |
sentence |
23817016 |
Subsequently, the Gaolf subunit activates the integral membrane protein adenylyl cyclase type III (AC3), leading to the conversion of adenosine triphosphate (ATP) into cyclic adenosine monophosphate (cAMP) |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
ADCY3 | up-regulates activity
binding
|
PKA |
0.519 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-278073 |
|
|
Homo sapiens |
HaCaT Cell |
pmid |
sentence |
33802009 |
Although the generated cAMP is primarily involved in transmitting odor information to the olfactory bulbs in the brain, it has been demonstrated that an increase in cellular cAMP by ADCY3 could stimulate protein kinase A (PKA) signaling, which is well-known to regulate diverse physiological and pathological processes |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
NF1 | up-regulates
|
ADCY3 |
0.267 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-204034 |
|
|
Homo sapiens |
|
pmid |
sentence |
24431436 |
Nf1encodes neurofibromin, a protein with multiple functions including ras inactivation (ras gtpase-activating protein or rasgap) and adenylyl cyclase (ac) activation |
|
Publications: |
1 |
Organism: |
Homo Sapiens |