3.0
Summary
| Name |  MARCHF6
|
| Full Name | E3 ubiquitin-protein ligase MARCHF6 |
| Synonyms | Doa10 homolog, Membrane-associated RING finger protein 6, Membrane-associated RING-CH protein VI, MARCH-VI, Protein TEB-4, RING finger protein 176, RING-type E3 ubiquitin transferase MARCHF6 | KIAA0597, MARCH6, RNF176, TEB4 |
| Primary ID | O60337 |
| Links |  -  -  |
| Type | protein |
| Relations | 1 |
| Function | E3 ubiquitin-protein ligase that promotes 'Lys-48'-linked ubiquitination of target proteins, leading to their proteasomal degradation (PubMed:15673284). Promotes ubiquitination of DIO2, leading to its degradation (PubMed:19651899). Promotes ubiquitination of SQLE, leading to its degradation (PubMed:24449766). E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. May cooperate with UBE2G1 (PubMed:15673284). |
ubiquitination