Relation Results

Summary

Name TLR5
Full Name Toll-like receptor 5
Synonyms Toll/interleukin-1 receptor-like protein 3 | TIL3
Primary ID O60602
Links - -
Type protein
Relations 2
Function Pattern recognition receptor (PRR) located on the cell surface that participates in the activation of innate immunity and inflammatory response (PubMe ...
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Type: Score: Layout: SPV 
0.3550.47PRKD1TLR5IL6

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▶Modifications Tables

Relations
Regulator
Mechanism
target
score ℹ
+ PRKD1up-regulates img/direct-activation.png phosphorylation TLR5 0.355
Identifier Residue Sequence Organism Cell Line
SIGNOR-154473 Ser805 YQLMKHQsIRGFVQK Homo sapiens HEK-293T Cell
pmid sentence
Pkd phosphorylated the tlr5-derived target peptide in vitro, and phosphorylation of the putative target serine 805 in hek 293t cell-derived tlr5 was identified by mass spectrometry. These results demonstrate that both pkd1 and pkd2 are required for inflammatory responses following tlr2, tlr4, or tlr5 activation, although pkd1 is more strongly involved
Publications: 1 Organism: Homo Sapiens
+ TLR5up-regulates quantity by expression img/indirect-activation.png transcriptional regulation IL6 0.47
Identifier Residue Sequence Organism Cell Line
SIGNOR-259868 Homo sapiens
pmid sentence
These studies demonstrate a novel function of Toll-like receptor-5 (TLR5) in a human multiple myeloma (MM) cell line, KMS28BM. These cells express high levels of both TLR5 mRNA and protein. When cells were treated with the specific TLR5 ligand flagellin, proliferation was increased, and the secretion of IgG λ antibody and the expression of the pro-inflammatory cytokine IL-6 were increased via NF-κB activation through PI3K/AKT and p38 signaling.
Publications: 1 Organism: Homo Sapiens
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