Summary

Name EIF5B
Full Name Eukaryotic translation initiation factor 5B
Synonyms eIF-5B, Translation initiation factor IF-2 | IF2, KIAA0741
Primary ID O60841
Links - -
Type protein
Relations 4
Pathways Initiation of Translation
Function Plays a role in translation initiation. Translational GTPase that catalyzes the joining of the 40S and 60S subunits to form the 80S initiation complex with the initiator methionine-tRNA in the P-site base paired to the start codon. GTP binding and hydrolysis induces conformational changes in the enzyme that renders it active for productive interactions with the ribosome. The release of the enzyme after formation of the initiation complex is a prerequisite to form elongation-competent ribosomes.

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Relations

Regulator Mechanism target score ℹ
+ EIF5Bup-regulates activity img/direct-activation.png relocalization Met-tRNA(Met) 0.8
Publications: 1 Organism: Homo Sapiens
Pathways:Initiation of Translation
+ EIF5up-regulates activity img/direct-activation.png relocalization EIF5B 0.741
Publications: 1 Organism: Homo Sapiens
Pathways:Initiation of Translation
+ EIF5Bdown-regulates activity img/direct_inhibition.png binding 60S cytosolic large ribosomal subunit 0.607
Publications: 1 Organism: Homo Sapiens
Pathways:Initiation of Translation
+ EIF5Bdown-regulates activity img/direct_inhibition.png binding 40S cytosolic small ribosomal subunit 0.661
Publications: 1 Organism: Homo Sapiens
Pathways:Initiation of Translation