Summary

Name RAMP3
Full Name Receptor activity-modifying protein 3
Synonyms Calcitonin-receptor-like receptor activity-modifying protein 3, CRLR activity-modifying protein 3 |
Primary ID O60896
Links - -
Type protein
Relations 2
Function Accessory protein that interacts with and modulates the function of G-protein coupled receptors including calcitonin gene-related peptide type 1 receptor (CALCRL), calcitonin receptor (CALCR) and G-protein coupled estrogen receptor 1 (GPER1) (PubMed:23674134, PubMed:9620797). Required for the transport of CALCRL and GPER1 receptors to the plasma membrane (PubMed:23674134, PubMed:9620797). Plays a role in cardioprotection by reducing cardiac hypertrophy and perivascular fibrosis in a GPER1-dependent manner (PubMed:23674134). Together with CALCRL, form a receptor complex for adrenomedullin/ADM and intermedin/ADM2 (PubMed:32296767). Together with CALCR, act as a receptor complex for amylin/IAPP (PubMed:35324283).

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Relations

Regulator Mechanism target score ℹ
+ RAMP3form complex img/form-complex.png binding Amylin receptor 3 complex 0.725
Publications: 1 Organism: Homo Sapiens
+ RAMP3form complex img/form-complex.png binding Adrenomedullin receptor AM2 complex 0.785
Publications: 1 Organism: Homo Sapiens