Name RNF40
Full Name E3 ubiquitin-protein ligase BRE1B
Synonyms BRE1-B, 95 kDa retinoblastoma-associated protein, RBP95, RING finger protein 40 | BRE1B, KIAA0661
Primary ID O75150
Links - -
Type protein
Relations 1
Function Component of the RNF20/40 E3 ubiquitin-protein ligase complex that mediates monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1). H2BK120ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation (H3K4me and H3K79me, respectively). It thereby plays a central role in histone code and gene regulation. The RNF20/40 complex forms a H2B ubiquitin ligase complex in cooperation with the E2 enzyme UBE2A or UBE2B; reports about the cooperation with UBE2E1/UBCH are contradictory. Required for transcriptional activation of Hox genes.



Regulator Mechanism target score
+ up-regulates img/direct-activation.png phosphorylation RNF40 0.14
Publications: 1 Organism: Homo Sapiens