Summary

Name RAB11FIP3
Full Name Rab11 family-interacting protein 3
Synonyms FIP3-Rab11, Rab11-FIP3, Arfophilin-1, EF hands-containing Rab-interacting protein, Eferin, MU-MB-17.148 | ARFO1, KIAA0665
Primary ID O75154
Links - -
Type protein
Relations 1
Function Acts as a regulator of endocytic traffic by participating in membrane delivery. Required for the abcission step in cytokinesis, possibly by acting as an 'address tag' delivering recycling endosome membranes to the cleavage furrow during late cytokinesis. Also required for the structural integrity of the endosomal recycling compartment during interphase. May play a role in breast cancer cell motility by regulating actin cytoskeleton. Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non-processive to a highly processive motor in the presence of dynactin. Facilitates the interaction between dynein and dynactin and activates dynein processivity (the ability to move along a microtubule for a long distance without falling off the track) (PubMed:25035494).

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates quantity img/direct-activation.png phosphorylation RAB11FIP3 0.2
Publications: 1 Organism: Homo Sapiens