Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-273587 |
Ser771 |
ESGPRCSsPVDTECS |
in vitro |
|
pmid |
sentence |
29764989 |
We found that many interactions were abolished upon kinase inhibition; however, a subset was protected from phosphatase opposition or was unopposed, resulting in persistent interaction of the substrate with Plk1. This subset includes phosphoprotein phosphatase 6 (PP6), whose activity toward Aurora kinase A (Aurora A) was inhibited by Plk1. Our data suggest that this Plk1-PP6 interaction generates a feedback loop that coordinates and reinforces the activities of Plk1 and Aurora A during mitotic entry and is terminated by the degradation of Plk1 during mitotic exit. |
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