Relation Results

Summary

Name PPP6R2
Full Name Serine/threonine-protein phosphatase 6 regulatory subunit 2
Synonyms SAPS domain family member 2 | KIAA0685, PP6R2, SAPS2
Primary ID O75170
Links - -
Type protein
Relations 1
Function Regulatory subunit of protein phosphatase 6 (PP6). May function as a scaffolding PP6 subunit. Involved in the PP6-mediated dephosphorylation of NFKBIE ...
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Type: Score: Layout: SPV 
0.261CDK1PPP6R2

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▶Modifications Tables

Relations
Regulator
Mechanism
target
score ℹ
+ CDK1down-regulates activity img/direct_inhibition.png phosphorylation PPP6R2 0.261
Identifier Residue Sequence Organism Cell Line
SIGNOR-273587 Ser771 ESGPRCSsPVDTECS in vitro
pmid sentence
We found that many interactions were abolished upon kinase inhibition; however, a subset was protected from phosphatase opposition or was unopposed, resulting in persistent interaction of the substrate with Plk1. This subset includes phosphoprotein phosphatase 6 (PP6), whose activity toward Aurora kinase A (Aurora A) was inhibited by Plk1. Our data suggest that this Plk1-PP6 interaction generates a feedback loop that coordinates and reinforces the activities of Plk1 and Aurora A during mitotic entry and is terminated by the degradation of Plk1 during mitotic exit.
Publications: 1 Organism: In Vitro
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