Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-119090 |
Ser30 |
RNLLEDDsDEEEDFF |
Homo sapiens |
|
pmid |
sentence |
14608369 |
The r-snare vamp4, which contains a dileucine motif, binds to the ap-1 or the ggas. Serine 20 and leucines 25,26 are essential for this binding. Ap-1 association with vamp4 is enhanced when serine 30 is phosphorylated by casein kinase 2. This phosphorylation-dependent modulation of ap-1 binding is mediated by pacs-1 (phosphofurin acidic cluster sorting protein). Ablation of both the dileucine motif and serine 30 results in a dramatic mislocalization of vamp4 in the regulated secretory pathway. |
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